Monthly Archives: February 2019

1P LSD first debuted online as a research chemical in 2015. It has been sold as a designer psychedelic drug ever since. Little is known about its invention as academic literature about the substance does not exist prior to its debut online. Due to the lack of analytical, chemical, and pharmacological data on 1P LSD,1p lsd for sale. Conclusive scientific evidence is lacking on its properties, behavior, and risks. However, it is assumed that 1P LSD functions similarly to LSD. According to user accounts, its subjective effects are almost identical. 

1P LSD is considered an analogue to LSD.  An analogue is a substance that is structurally and functionally similar to the original substance. It was created by modifying the molecular structure of LSD, probably in an attempt to produce a novel derivative of LSD that would technically fall into a legal loophole in many countries. 1P LSD is also a homologue of ALD-52, which means that a molecular chain was added to its parent molecule.

The United States does not control 1P LSD on the federal level. However, it could be considered an analogue, which would make it illegal under the Federal Analogue Act.

What You Will Learn About 1P LSD

  • 1P LSD is a psychedelic substance of the lysergamide class and is considered an analogue of LSD and homologue of ALD-52. It also could be a “prodrug” of LSD. 
  • The legality of 1P LSD varies from country to country. However, it is illegal in 13 countries.
  • Because it is so closely related to LSD, it is considered relatively safe to use. However, there are increased risks if you have a pre-existing medical condition, heart condition, or are on certain kinds of medications.
  • 1P LSD first appeared online in 2015 as a designer drug. We don’t know who first created it, although some speculate that it was Alexander Shulgin.

What is 1P LSD? 

1P LSD is short for 1-propionyl-lysergic acid diethylamide. As an analogue of LSD and homologue of ALD-52, it is classified as a psychedelic substance of the lysergamide class. 1P LSD is made by adding a propionyl group to the nitrogen molecule of LSD’s indole. In other words, it is the same substance as LSD with an additional chemical chain. Recently, it has become available as a research chemical in the form of blotters and powdered material. Typically, it takes 45-90 minutes to begin to feel the effects and lasts anywhere between 8-12 hours,1p lsd for sale. 

Pharmacology

Though 1P LSD functions similarly to LSD, too little research exists to make definitive claims. However, due to its chemical similarities, it functions as a serotonergic substance. It binds to the 5-HT serotonin receptors in the brain or body. The way LSD binds to the 5-HT2A receptor, in particular, causes a cross-activation of the 5-HT2A receptor heteromer. In other words, this relationship produces long-lasting psychedelic effects. 1P-LSD probably binds with the monoamine receptors responsible for dopamine and norepinephrine but, again, little data exists to back up these claims.  

A study from 2015 indicated that 1P-LSD shows 38% the potency of LSD in mice, though the drug did exhibit LSD-like behavior. There is a theory that 1P-LSD may act as a prodrug for LSD, which would mean that it turns into LSD once metabolized in the body. However, more studies need to be conducted in order to determine how 1P-LSD functions and if it is capable of producing its own psychedelic effects.

1P LSD & LSD: What’s the Difference?

Subjectively speaking, users claim that the effects are more or less identical. However, a recent study investigated the similarities and differences in mice. Researchers found that 1P LSD shows 38% of the potency of LSD. This could indicate that 1P LSD is a prodrug, which means that it metabolizes into LSD in the body. The process could make 1P LSD weaker in comparison as well as slower to take effect. According to users, however, this does not seem to accurately reflect their experiences,1p lsd for sale . 

The main differences include:

  • Molecular weight: LSD, 320g/mol | 1P LSD, 380g/mol.
  • 1P LSD: has three more carbons and one more oxygen in its molecular structure than LSD has. 
  • Legalities: LSD is an illegal drug in most countries. 1P LSD is a research chemical and is legal.
  • Effects: 1P LSD may be more stimulating and fast-paced in regard to its physical and cognitive effects. However, overall, the average user expresses that they cannot tell the difference.

Benefits & Risks

Concerning the risks and benefits of 1P LSD, know how much you’re taking and what kind of experience you are looking for. If you’re new to psychedelics, doing it alone might not be advisable. An unfavorable set and setting could potentiate a series of issues. 

If you’re taking medications or have a pre-existing condition, particularly those defined as cardiovascular or mental, then consult a trained physician or expert before taking any substance. There is a risk of vasoconstriction in the heart, and psychosis for bipolar disorder and schizophrenia,1p lsd for sale. Furthermore, mixing certain pharmaceutical drugs may counter-interact with 1P LSD as well. Benzodiazepine tends to lower the effectiveness of lysergic acid diethylamide and any other psychedelic substance. Mixing certain antidepressants with LSD can result in serotonin syndrome due to an overload of serotonin in the central nervous system. 

Other concerns include HPPD and PTSD. HPPD, or hallucinogen persisting perception disorder, is a disorder where users see “visual snow” long after the trip has ended. This can disrupt an individual’s ability to perform regular tasks due to the distraction caused by visual snow. In more extreme cases HPPD can result in severe hallucinations for prolonged periods of time.

All these factors indicate the need for preparation and forethought to reduce the risks of taking 1P LSD.

Aside from that, the risks of 1P LSD are technically unknown. Since science governs the area of medicine, when we speak about a substance we cannot make definite claims about them unless backed up by science. Personal accounts, even if there are thousands, cannot technically be credited as factual.  However, 1P LSD appears to function like LSD, which would make it a relatively low-risk drug since scientific evidence on LSD shows that there are minimal adverse effects.

Top Reported Benefits

Recently, a resurged interest in LSD has led scientists to reconsider the studies that were conducted in the 50s and 60s. Those investigations primarily focused on treating depression, post-traumatic stress disorder, drug dependency, and reducing anxiety in end-of-life patients. Since the effects are similar to LSD, it might be able to address these issues and their associated symptoms.

The top reported benefits include:

  • Dissolution of the ego.
  • A decrease in anxiety and depression.
  • Euphoria.
  • Spiritual enhancement and feelings of unity.
error: