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Buy 3-meo-pcp online



Buy 3-meo-pcp online. 3-Methoxyphencyclidine (3-MeO-PCP) is a dissociative hallucinogen of the aryl cyclohexylamine class related to phencyclidine (PCP) which has been sold online as a designer drug. It acts mainly as an NMDA receptor antagonist, though we have also found it to interact with the sigma σ1 receptor and the serotonin transporter. The drug does not possess any opioid activity, nor does it act as a dopamine reuptake inhibitor.


3-MeO-PCP has a Ki of 20 nM for the dizocilpine (MK-801) site of the NMDA receptor, 216 nM for the serotonin transporter (SERT), and 42 nM for the sigma σ1 receptor. It does not bind to the norepinephrine or dopamine transporter nor to the sigma σ2 receptor (Ki >10,000 nM). Based on its structural similarity to 3-hydroxy-PCP (3-HO-PCP), which uniquely among aryl cyclohexylamines has high affinity for the μ-opioid receptor besides the NMDA receptor, it was initially expected that 3-MeO-PCP would have opioid activity. However, radioligand binding assays with human proteins have shown that, contrary to common belief, the drug also does not interact with the μ-, δ-, or κ-opioid receptors at concentrations of up to 10,000 nM. The notion that 3-MeO-PCP has opioid activity has been described as a myth.

It  binds to the NMDA receptor with higher affinity than PCP and has the highest affinity of the three isomeric anisyl-substitutions of PCP, followed by 2-MeO-PCP and 4-MeO-PCP.

Buy 3-MeO-PCP online. 3-Meo-PCP acts as an NMDA receptor antagonist. A specific subtype of glutamate receptor, NMDA (N-Methyl-D-Aspartate), modulates the transmission of electrical signals between neurons in the brain and spinal cord; for the signals to pass, the receptor must be open.

Dissociatives inhibit the normal functioning NMDA receptors by binding to and blocking them. This disruption of neural network activity leads to loss of normal cognitive and affective processing, psychomotor functioning, anesthesia and eventually the equivalent of a “k-hole”.

3-MeO-PCP has a Ki of 20 nM for the NMDA receptor, 216 nM for the serotonin transporter (SERT), 42 nM for the sigma-1 receptor and 2960 nM with H₁ receptor It binds to the NMDA receptor with higher affinity than PCP and has the highest affinity of the three isomers  anisyl-substitutions, followed by 2-MeO-PCP and 4-MeO-PCP.

Although 3-MeO-PCP was once claimed to possess opioid or dopaminergic activity, this supposition is contradicted by data showing 3-MeO-PCP to be a potent and selective ligand for the NMDA receptor without appreciable affinity for the µ-opioid receptor or dopamine transporter. the less preceded 3-MeO-PCP potent dissociative 4-MeO-PCP and first became available as a research chemical in 2011


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