4-HO-DPT is a synthetic compound that is not known to occur in nature. However, in 1990, mushroom researcher Jochen Gartz patented a method for adding DPT to mushroom growth medium which resulted in the mushroom fruiting bodies containing 4-HO
4-HO-DPT is a psilocybin derivative and a structural homolog of psilocin. Repke et al. were first to report the synthesis of 4-HO-DPT in 1977.2
In October 2019, researchers solved the crystal structure of 4-HO-DPT.3 They describe the structure as “…a singly protonated DPT cation, one half of a fumarate dianion (completed by a crystallographic centre of symmetry) and two water molecules of crystallization in the asymmetric unit.”
Little is known about the pharmacology Alexander and Ann Shulgin documented their synthesis of 4-HO-DPT , and describe a 20 mg oral dose as, “Possible threshold, nothing more.” 4
The new crystal structure of 4-HO discussed earlier opens to door to understanding its physical properties. This discovery also allows scientists to test its activity at biological receptors.
The Applications and Potential
Prior to the current work to solve its crystal structure, virtually nothing was known about 4-HO-DPT. Characterizing this fundamental structure is essential for all downstream research, such as structure-activity relationships that define the biological and clinical properties of the molecule. Understanding these relationships is key to developing effective drugs.
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4-HO-DPT (also known as 4-hydroxy-N,N-dipropyltryptamine and sometimes Procin) is a psychedelic substance that resides in the tryptamine class. It is the 4-hydroxyl analog of DPT.
Very little data exists about the pharmacological properties, metabolism, and toxicity of 4-HO-DPT, so look after your research subjects.
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