4-HO-MET (4-hydroxy-N-methyl-N-ethyltryptamine, metocin, or methylcybin), is a lesser-known psychedelic drug. It is a structural and functional analog of psilocybin, and the 4-hydroxyl analog of methylethyltryptamine (MET). 4-HO-MET was first synthesized by Alexander Shulgin. In his book TiHKAL (Tryptamines I Have Known and Loved), we list the dosage as 10-20 mg. 4-HO-MET produces psilocybin like distortion of color, sound, and form. Very little data exists about the pharmacological properties, metabolism, and toxicity of 4-HO-MET. There have been no reports of deaths from 4-HO-MET, even though people have reported taking doses up to 150 mg, more than an order of magnitude above the effective dose.4-HO-DPT
4-HO-DPT is a psilocybin derivative and a structural homolog of psilocin. Repke et al. were first to report the synthesis of 4-ho-met in 1977.2
In October 2019, the researchers solved the crystal structure of 4-ho-met They describe the structure as “… a singly protonated DPT cation, one half of a fumarate dianion (completed by a crystallographic centre of symmetry) and two water molecules of crystallization in the asymmetric unit.”
We know little about the pharmacology Alexander and Ann Shulgin documented their synthesis of 4-ho-met, and describe a 20 mg oral dose as, “ threshold, nothing more.” 4
The new crystal structure of 4-HO discussed earlier opens the door to understanding its physical properties. This discovery also allows scientists to test its activity at biological receptors.
The Applications and Potential
Prior to the current work to solve its crystal structure, they knew virtually nothing about 4-HO-DPT. Characterizing this fundamental structure is essential for all downstream research, such as structure-activity relationships that define the biological and clinical properties of the molecule. Understanding these relationships is key to developing effective drugs.
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4-HO-DPT (also known as 4-hydroxy-N,N-dipropyltryptamine and sometimes Procin) is a psychedelic substance that lives in the tryptamine class. It is the 4-hydroxyl analog of DPT.
Very little data exists about the pharmacological properties, metabolism, and toxicity of 4-HO-DPT, so look after your research subjects.
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